What are the Long Term Effects of Trazodone?

**Understanding the Long-Term Effects of Trazodone**

Trazodone is a medication often prescribed for depression and off-label for sleep issues. While it’s generally safe when used as directed, long-term use or misuse can lead to specific risks. Here’s what you need to know in plain terms:

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### **Common Long-Term Risks**
– **Serotonin Syndrome**: Too much serotonin in the body can cause agitation, sweating, fever, or even organ damage if untreated[1][5].
– **Low Sodium Levels**: This may trigger confusion, seizures, or fainting[5].
– **Heart Issues**: Irregular heartbeat (arrhythmia) or QT prolongation—a heart rhythm problem—can occur[1][4].
– **Vision Problems**: Blurred vision, eye pain, or swelling may develop over time; regular eye checkups are advised[1][5].
– **Blood Pressure Drops**: Standing up quickly might cause dizziness or fainting due to low blood pressure[1][4].

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### **Less Common but Serious Effects**
– **Priapism**: A painful erection lasting over 6 hours requires immediate medical help to avoid permanent damage[1][4].
– **Mood Swings**: Rarely, trazodone can trigger manic episodes (extreme energy/irritability)[1][4].

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### **Dependence and Withdrawal**
Even though trazodone isn’t addictive like opioids, stopping suddenly after long-term use can cause withdrawal symptoms such as anxiety, insomnia, and mood swings. Doctors usually recommend tapering doses slowly to avoid these issues[5].

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### **Who Should Be Extra Cautious?**
People with heart conditions, bipolar disorder, or a history of low sodium levels should discuss risks with their doctor before using trazodone long-term[3][4].

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### Final Takeaway: Stay Safe!
Always follow your doctor’s dosage instructions and report unusual symptoms immediately. Regular checkups help catch side effects early—don’t skip them! If you plan to stop taking trazodone after prolonged use *never* quit cold turkey; work with your healthcare provider on a gradual plan[3][5].