Chronic inflammation has been identified as a significant factor in the development of dementia. Research shows that conditions like heart disease, diabetes, and stroke, which are part of cardiometabolic clusters, increase the risk of dementia due to shared underlying pathologies such as atherosclerosis and inflammation[1]. Inflammation can lead to reduced cerebral blood flow, contributing to neuronal dysfunction and cognitive decline[1].
To potentially reverse or reduce this risk, several strategies can be employed. Long-term use of anti-inflammatory medications like NSAIDs has been linked to a lower risk of dementia, though their long-term use is not recommended due to potential side effects[3][5]. A healthier approach includes maintaining a diet rich in omega-3s and antioxidants, such as the Mediterranean diet, and engaging in regular exercise and mental stimulation[4]. Additionally, managing stress and maintaining social connections can also play a role in protecting cognitive health[4].
