How to Use Medication to Manage Dementia-Related Aggression and Agitation

Managing aggression and agitation in people with dementia can be challenging, but medication can play a crucial role in helping to alleviate these symptoms. It’s essential to understand that these behaviors are often not intentional but rather a response to unmet needs or environmental stressors. Here’s a straightforward guide on how to use medication effectively:

First, it’s important to identify the underlying causes of aggression and agitation. These can include pain, confusion, or discomfort, which may be exacerbated by changes in the environment or communication difficulties. Once you’ve pinpointed the triggers, you can work with healthcare professionals to develop a personalized treatment plan.

Medications for managing agitation and aggression in dementia fall into several categories:

1. **Antidepressants**: For mild to moderate agitation, antidepressants like Celexa (citalopram) or Lexapro (escitalopram) can help reduce anxiety and irritability. These medications are often used because they have fewer side effects compared to other options[2].

2. **Antipsychotics**: In cases of severe agitation or aggression, antipsychotics such as Seroquel (quetiapine) or Risperdal (risperidone) may be prescribed. However, these should be used with caution due to potential side effects[2][5].

3. **Benzodiazepines**: Medications like Ativan (lorazepam) are sometimes used for short-term relief of severe agitation, but they also carry risks and should be used sparingly[2].

4. **New Developments**: Recently, medications like Rexulti (brexpiprazole) have been approved for treating agitation in Alzheimer’s disease, offering new hope for managing these symptoms[2]. Additionally, AXS-05, an oral NMDA receptor antagonist, has shown promise in preventing agitation relapse in Alzheimer’s patients[3].

When using medication, it’s crucial to monitor the person’s response closely and adjust the treatment plan as needed. Medication should be part of a broader strategy that includes creating a calm environment, providing meaningful activities, and ensuring the person’s physical and emotional needs are met.

Ultimately, managing aggression and agitation in dementia requires a comprehensive approach that combines medication with non-pharmacological interventions. By working closely with healthcare professionals and understanding the individual’s needs, you can help create a more peaceful and supportive environment for those affected by dementia.