Can medications reduce the risk of dementia? This question has been on the minds of researchers and the public alike. Recent studies have shed some light on this topic, particularly focusing on a common class of drugs many people already use: non-steroidal anti-inflammatory drugs (NSAIDs).
A large study conducted by researchers at Erasmus University Medical Center in Rotterdam followed nearly 12,000 people for about 14.5 years[9]. They found that long-term use of NSAIDs, which includes medications like ibuprofen and aspirin, was linked to a 12% lower risk of developing dementia[3][9].
But here’s the catch – it’s not just about popping a pill every now and then. The study showed that only long-term use (more than 24 months) had this protective effect[9]. Short-term or occasional use didn’t seem to help and might even slightly increase the risk[9].
Why might these drugs help? Scientists think it’s because of their anti-inflammatory properties. Inflammation in the brain is believed to play a role in the development of dementia[1]. NSAIDs might help by reducing this inflammation over time.
Interestingly, the study found that the total amount of NSAIDs taken didn’t matter as much as how long people took them[9]. This suggests that it’s the consistent, long-term exposure to these anti-inflammatory effects that might be key.
It’s not just NSAIDs that are showing promise. Another recent study looked at various types of medications and their effects on dementia risk[1]. They found that antibiotics, antivirals, blood thinners, and anti-seizure medications were all associated with a lower risk of dementia[1].
However, it’s crucial to note that while these findings are exciting, they don’t mean everyone should start taking NSAIDs or other medications long-term to prevent dementia. These drugs can have serious side effects, especially when used for extended periods. They can cause stomach ulcers, bleeding, and increase the risk of heart problems[3].
The researchers themselves emphasize that their results don’t justify recommending long-term NSAID use for dementia prevention[9]. More studies are needed to fully understand the relationship between these medications and dementia risk.
In the meantime, there are other ways to potentially reduce your risk of dementia that don’t involve medication. Staying physically active, eating a healthy diet, keeping your mind engaged, and maintaining social connections are all strategies that have been associated with better brain health as we age.
The search for ways to prevent or treat dementia is ongoing, and while medications might play a role in the future, it’s clear that a holistic approach to brain health is important. As always, any decisions about medication should be made in consultation with a healthcare provider who can weigh the potential benefits against the risks for each individual.
