Can fasting-mimicking diets help prevent dementia? This is a question many researchers are exploring as they search for ways to combat cognitive decline in aging populations.
Fasting-mimicking diets (FMDs) are eating patterns designed to provide the benefits of fasting while still allowing some food intake. They typically involve several days of very low calorie consumption, followed by normal eating.
Some studies have shown promising results for FMDs in terms of brain health. Research in mice found that cycles of FMD reduced brain inflammation and stimulated the growth of new brain cells[1]. This could potentially help protect against cognitive impairment.
In humans, FMDs have been found to lower risk factors associated with dementia, like high blood sugar, inflammation, and excess body fat[1]. One study showed FMD cycles improved memory performance in older adults at risk for cognitive decline[1].
The exact mechanisms aren’t fully understood, but FMDs seem to trigger cellular “recycling” processes that clear out damaged components. They may also boost production of ketones, an alternative brain fuel that some research suggests could be neuroprotective[1].
However, it’s important to note that research is still in early stages. While animal studies and small human trials show potential, large long-term studies are needed to confirm if FMDs can truly prevent dementia in humans[1].
Additionally, fasting-type diets aren’t appropriate for everyone. They can be risky for people with certain health conditions or a history of disordered eating. Anyone considering an FMD should consult their doctor first.
In the meantime, other lifestyle factors like regular exercise, social engagement, and a healthy overall diet are well-established ways to support brain health as we age. These should remain the foundation of dementia prevention efforts.
So while fasting-mimicking diets show some early promise for cognitive health, more research is needed before they can be recommended as a dementia prevention strategy. For now, they remain an intriguing area of study in the quest to keep our brains healthy as we get older.
