## Can Single-Cell RNA-Seq Map Pathogenic Immune Cell States in Multiple Sclerosis Lesions? Multiple sclerosis (MS) is a complex disease where the immune system mistakenly attacks the protective covering of nerve fibers in the brain and spinal cord. This leads…
CXCL13 plays a crucial role as a biomarker for intrathecal B-cell activity by serving as a key chemokine that attracts B cells into the central nervous system (CNS), particularly within the cerebrospinal fluid (CSF). Its presence and elevated levels in…
Cerebrospinal fluid (CSF) complement proteins serve as important indicators of **compartmentalized inflammation** within the central nervous system (CNS) in multiple sclerosis (MS). These proteins reflect localized immune activity distinct from systemic inflammation, highlighting how the immune response in MS is…
Metabolomic signatures have the potential to differentiate multiple sclerosis (MS) subtypes by revealing unique biochemical patterns associated with each form of the disease. MS is a complex neurological disorder characterized by immune-mediated damage to the central nervous system, and it…
## Understanding Plasma Tau and Its Role in Multiple Sclerosis Neurodegeneration Multiple sclerosis (MS) is a complex disease where the immune system mistakenly attacks the protective covering of nerve fibers, leading to inflammation, demyelination, and eventually neurodegeneration. While much attention…
Multiple sclerosis (MS) is a complex disease where the immune system attacks the brain and spinal cord, leading to symptoms like fatigue, vision problems, muscle weakness, and trouble with coordination. One of the biggest challenges in managing MS is predicting…
## Understanding Neurofilament Dynamics and Treatment Response Timing Neurofilaments are like the scaffolding inside nerve cells—they help keep the cell’s shape, support its structure, and play a key role in how nerves communicate. When something goes wrong with these neurofilaments,…
Inertial sensors have emerged as a promising tool in the field of healthcare, particularly in monitoring and assessing the risk of falls among individuals with progressive multiple sclerosis (MS). Progressive MS is characterized by a steady worsening of symptoms without…
The best metrics for assessing real-world walking and balance in people with multiple sclerosis (MS) focus on capturing subtle changes in gait stability, postural control, and balance performance rather than just simple measures like walking speed. These metrics provide a…
Speech analytics shows promising potential for detecting early cognitive impairment in people with Multiple Sclerosis (MS) by analyzing subtle changes in how they speak. Cognitive decline in MS can be difficult to identify early because it may not always correlate…