Therapeutic vaccines targeting Epstein-Barr virus (EBV) hold promising potential to prevent multiple sclerosis (MS) in individuals at high risk, though this approach is still under active research and development. EBV is a common herpesvirus that infects most people worldwide and…
Multiple sclerosis (MS) is a complex disease where the immune system mistakenly attacks the protective covering of nerves in the brain and spinal cord. This leads to symptoms like fatigue, vision problems, muscle weakness, and trouble with coordination. While we…
Cold-climate exposure may influence the prevalence and characteristics of multiple sclerosis (MS) beyond the well-known effects of vitamin D deficiency, but this relationship is complex and not fully understood. While vitamin D, produced in the skin through sunlight exposure, has…
Shift work, circadian disruption, and multiple sclerosis (MS) risk are interconnected through complex biological and environmental mechanisms that influence immune function, inflammation, and neurological health. Understanding this association requires exploring how the body’s internal clock, or circadian rhythm, regulates immune…
Environmental toxins and solvents can influence the incidence of multiple sclerosis (MS) by contributing to the damage of the nervous system’s protective myelin sheath and by triggering immune system dysfunction. MS is a chronic autoimmune disease where the immune system…
PET-myelin imaging is a cutting-edge technique that has been gaining attention for its potential to visualize and quantify myelin in the brain. Myelin is a crucial component of the nervous system, acting as an insulating layer around nerve fibers, which…
PET ligands play a crucial role in detecting and understanding microglial activation in multiple sclerosis (MS), which is a chronic inflammatory disease of the central nervous system characterized by demyelination and neurodegeneration. Microglia are the resident immune cells of the…
## Can Quantitative MRI Myelin Mapping Serve as a Trial Endpoint? Imagine you’re a scientist trying to figure out if a new drug helps protect the brain after injury, or if a therapy slows down diseases like multiple sclerosis. You…
## Understanding Spinal Cord Lesions in Multiple Sclerosis Multiple sclerosis (MS) is a chronic disease where the immune system mistakenly attacks the protective covering of nerve fibers, called myelin, in the brain and spinal cord. When this happens in the…
Cortical lesion detection holds significant promise for refining prognosis in early multiple sclerosis (MS) by providing deeper insights into disease progression and potential disability outcomes. Unlike the more commonly recognized white matter lesions, cortical lesions occur in the brain’s outer…