Heat sensitivity and Uhthoff’s phenomenon are closely related to conduction block in nerve fibers, particularly in the context of demyelinated axons such as those affected in multiple sclerosis (MS). When nerve fibers lose their myelin sheath, their ability to conduct…
Exercise can indeed synergize with disease-modifying therapies (DMTs) to help reduce brain atrophy in multiple sclerosis (MS) by promoting neuroplasticity, enhancing brain reserve, and supporting neural repair mechanisms alongside the pharmacological effects of DMTs. This combination may slow down the…
Statins, widely known as cholesterol-lowering drugs, have attracted significant interest for their potential role in neuroprotection, especially in progressive multiple sclerosis (MS). Progressive MS is a form of MS characterized by a steady worsening of neurological function over time, often…
Combination therapy has the potential to outperform monotherapy in refractory multiple sclerosis (MS), particularly in cases where patients do not respond adequately to single-agent treatments. Refractory MS refers to forms of the disease that continue to progress or relapse despite…
Ibudilast is a small molecule drug that has shown promise in slowing brain atrophy rates in progressive multiple sclerosis (MS), a form of MS characterized by gradual worsening of neurological function and brain tissue loss. It works primarily by inhibiting…
High-dose biotin, also known as vitamin B7 or vitamin H, has been explored as a potential treatment to improve function in people with progressive multiple sclerosis (MS), particularly in its primary and secondary progressive forms. Progressive MS is characterized by…
Clemastine, an antihistamine commonly used to treat allergies, has been gaining attention for its potential role in remyelination, a process crucial for repairing damaged nerve fibers in conditions like multiple sclerosis (MS). Remyelination involves the formation of new myelin sheaths…
## Mitochondrial-Targeted Antioxidants and Axonal Degeneration in Multiple Sclerosis Multiple sclerosis (MS) is a complex disease where the immune system mistakenly attacks the protective covering of nerve fibers, called myelin, in the brain and spinal cord. Over time, this leads…
## Sodium and Calcium Channel Blockers in Multiple Sclerosis: Impact on Neuroaxonal Injury Multiple sclerosis (MS) is a complex disease where the immune system mistakenly attacks the protective covering of nerve fibers, called myelin, in the central nervous system. Over…
The pipeline for remyelinating drugs targeting LINGO-1 and beyond involves a complex and evolving landscape of research and development aimed at repairing damaged myelin in neurological diseases such as multiple sclerosis (MS). LINGO-1 (Leucine-rich repeat and immunoglobulin-like domain-containing protein 1)…