Fertility preservation can be safely integrated for patients starting high-risk disease-modifying therapies (DMTs), but it requires careful planning, individualized assessment, and multidisciplinary coordination to balance treatment urgency with reproductive goals. High-risk DMTs, often used in conditions like cancer or autoimmune…
Long-term reproductive outcomes after exposure to different disease-modifying therapies (DMTs) in multiple sclerosis (MS) are a complex and evolving area of study, influenced by the type of DMT, timing of exposure relative to conception and pregnancy, and individual patient factors.…
Early aggressive treatment in multiple sclerosis (MS) has the potential to significantly alter the epidemiology of MS-related disability by reducing the accumulation of long-term disability and improving overall disease outcomes. This approach involves initiating high-efficacy therapies soon after diagnosis, rather…
Payer policies play a crucial role in shaping access to high-efficacy therapies for people with early multiple sclerosis (MS). These policies, established by insurance providers including Medicare, Medicaid, and private insurers, determine which treatments are covered, under what conditions, and…
Composite endpoints have the potential to better capture patient-meaningful change in multiple sclerosis (MS) trials by integrating multiple aspects of disease impact into a single measure, reflecting the complex and multifaceted nature of MS. Unlike single endpoints that focus on…
## Understanding “No Evidence of Progression” in Multiple Sclerosis Multiple sclerosis (MS) is a complex, unpredictable disease that affects the central nervous system. One of the biggest challenges for patients, doctors, and researchers is figuring out whether the disease is…
Home-based robotics can indeed support upper-limb rehabilitation in people with multiple sclerosis (MS) by providing accessible, repetitive, and task-oriented training that promotes motor recovery and functional improvement. These robotic systems enable patients to engage in therapy within their own homes,…
Virtual reality (VR) therapy is emerging as a powerful tool to enhance both balance and cognitive function in people with multiple sclerosis (MS). MS is a neurological condition that often impairs mobility, coordination, and mental processing, making everyday activities challenging.…
Closed-loop neuromodulation holds promising potential to improve mobility in people with progressive multiple sclerosis (MS) by directly modulating neural circuits involved in movement control. Progressive MS often leads to worsening motor symptoms such as muscle weakness, spasticity, and impaired coordination,…
Wearable electromyography (EMG) devices and gait analytics have become powerful tools for quantifying spasticity in people with multiple sclerosis (MS). Spasticity is a common and complex symptom in MS characterized by involuntary muscle stiffness and spasms, which disrupt normal movement…