Certain supplements can interfere with memory, either by causing side effects that affect cognitive function or by interacting with medications and brain chemistry in ways that impair memory.
Some supplements that may negatively impact memory include:
– **Excessive Vitamin B6**: While vitamin B6 is essential for brain health, very high doses can cause nerve damage and cognitive issues, including memory problems. However, moderate supplementation generally shows no benefit or harm to memory[1].
– **Dehydroepiandrosterone (DHEA)**: This hormone supplement has been promoted for brain health, but large studies have not found evidence that DHEA improves memory or cognitive function in older adults. Some potential benefits were noted in younger people, but overall it is not proven to help memory and may have side effects[1].
– **Creatine**: Commonly used for muscle performance, creatine may improve mental function in sleep-deprived individuals but does not necessarily enhance memory in well-rested people. It can cause mild side effects like stomach upset, which might indirectly affect cognitive performance[1][5].
– **Supplements that disrupt nutrient balance**: For example, low choline levels in the brain are linked to anxiety and cognitive issues. Since choline is essential for brain function, supplements that interfere with choline metabolism or cause imbalances could impair memory. However, choline supplementation itself is generally considered beneficial, especially if dietary intake is low[2].
– **Herbal supplements like Ginkgo biloba**: Despite popular belief, large studies have found no significant benefit of Ginkgo biloba on memory or cognitive decline. Using such supplements instead of proven treatments might delay effective care[1].
It is important to note that many vitamins and minerals, such as vitamin B12 and magnesium, support brain health and may slow cognitive decline when deficient, rather than impair memory when taken appropriately[3][4][6]. Problems arise mostly from excessive doses, poor supplement quality, or interactions with medications.
People considering supplements for memory or cognitive health should consult healthcare providers, especially if they have underlying conditions or take other medications. Some supplements can interact with drugs or cause side effects that indirectly affect memory.
Sources
https://www.ebsco.com/research-starters/complementary-and-alternative-medicine/natural-treatments-memory-and-mental
https://health.ucdavis.edu/welcome/news/headlines/low-choline-levels-in-the-brain-associated-with-anxiety-disorders/2025/11
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70864
https://pmc.ncbi.nlm.nih.gov/articles/PMC12568389/
https://www.uclahealth.org/news/article/why-everyones-talking-about-creatine
https://timesofindia.indiatimes.com/life-style/health-fitness/top-neurologist-reveals-the-best-mineral-for-your-brain-that-can-even-lower-the-risk-of-memory-loss/articleshow/125298014.cms
