Memantine is a medication commonly prescribed to help manage symptoms of moderate to severe dementia, including Alzheimer’s disease. While it is generally well tolerated, there are several side effects that users should be aware of.
Common side effects include dizziness, headache, confusion, and constipation. Some people may also experience fatigue, aches, and nausea. These symptoms are usually mild and tend to improve as the body adjusts to the medication. However, if they persist or worsen, it is important to consult a healthcare provider.
More serious side effects, although less common, require immediate medical attention. These include hallucinations and shortness of breath. Because memantine affects brain signals, these symptoms can indicate a more severe reaction to the drug.
Other reported side effects include somnolence (excessive sleepiness), restlessness, and aggression. Some patients may also experience changes in mood, such as depression or increased confusion. These effects can be particularly challenging for caregivers to manage.
Memantine works by regulating the activity of glutamate, a neurotransmitter involved in learning and memory. In Alzheimer’s disease, excess glutamate can damage brain cells. By blocking this excess, memantine helps slow the progression of symptoms but does not stop the disease.
It is important to monitor for side effects, especially when starting memantine or changing doses. Patients should report any unusual symptoms to their doctor promptly. Careful management can help balance the benefits of memantine with its potential risks.
Sources
https://www.dementiacarecentral.com/aboutdementia/treating/memantine/
https://www.israelpharm.com/faq/faq-what-are-the-most-common-side-effects-people-experience-when-taking-namenda-regularly/
https://www.droracle.ai/articles/443140/does-namenda-cause-somnolence
https://alzheimer.ca/en/about-dementia/dementia-treatment-options-developments/medications-for-alzheimers
https://go.drugbank.com/drugs/DB01043
https://psychopharmacologyinstitute.com/section/dementia-pharmacotherapy-from-cholinesterase-inhibitors-to-anti-amyloid-therapies/
