Magnesium supplements may indeed influence cognitive outcomes by supporting brain function, improving mood regulation, and potentially protecting against cognitive decline. Magnesium is a vital mineral involved in hundreds of biochemical reactions in the body, including those essential for brain health. It plays a key role in maintaining the electrical activity of nerve cells, supporting synaptic connections, and regulating neurotransmitters that influence mood and cognition.
One of the primary ways magnesium affects cognition is through its calming effect on the nervous system. It promotes the activity of GABA, a neurotransmitter that acts as the brain’s natural calming agent, helping to reduce anxiety and stress. By lowering cortisol, the stress hormone, magnesium helps the brain avoid being stuck in a state of overdrive, which can impair attention and memory. This calming effect also supports better sleep quality, which is crucial for cognitive processes like memory consolidation and learning.
Magnesium’s influence extends to improving attention and reducing hyperactivity, which is particularly relevant for conditions like ADHD. Children and adults with ADHD may experience better focus and fewer emotional outbursts when magnesium levels are adequate. This is because magnesium helps regulate the nervous system’s response to stimuli, allowing for smoother emotional regulation and improved cognitive control.
Beyond mood and attention, magnesium is essential for memory and learning. It supports the brain’s energy production and helps maintain the structure of DNA and genes, which are fundamental for healthy brain aging. Studies have found that higher magnesium intake is associated with larger brain volumes and fewer white matter lesions, both indicators of healthier brain aging and reduced risk of cognitive decline.
Magnesium also plays a protective role against brain inflammation, which is linked to neurodegenerative diseases like Alzheimer’s. Animal studies suggest that magnesium supplementation may reduce brain inflammation and improve cognitive function, although more human research is needed to confirm these effects.
In addition to its direct effects on the brain, magnesium supports overall physical health, which indirectly benefits cognition. It helps regulate blood sugar, blood pressure, and heart rhythm, all of which contribute to optimal brain function. Magnesium also supports the immune system and helps manage inflammation, further protecting brain health.
Magnesium’s role in maintaining telomeres—the protective caps on chromosomes that shorten with age—suggests it may help slow cellular aging, including in brain cells. This could contribute to preserving cognitive function over time.
Different forms of magnesium supplements, such as magnesium glycinate, are often used because they are better absorbed and gentler on the digestive system. Supplementation can be particularly helpful for individuals who have lo





