Tecfidera, a medication commonly prescribed for multiple sclerosis (MS), **can cause hair thinning** in some patients, although this side effect is generally **not severe or permanent**. Hair thinning linked to Tecfidera tends to be mild and temporary, often improving without the need to stop the medication.
Tecfidera’s active ingredient is dimethyl fumarate, which works by modulating the immune system to reduce MS relapses and slow disease progression. Like other disease-modifying therapies (DMTs) for MS, Tecfidera can affect hair growth cycles, leading to thinning or shedding of hair in some individuals. This occurs because immune-modulating drugs can sometimes disrupt the normal hair follicle cycle, causing more hairs to enter the shedding phase prematurely.
While hair thinning is a recognized side effect, it is less commonly reported with Tecfidera compared to other MS medications such as teriflunomide or fingolimod, which have a higher incidence of hair loss. When hair thinning does occur with Tecfidera, it usually starts within the first few months of treatment and tends to improve over time as the body adjusts to the medication.
The mechanism behind hair thinning with Tecfidera is not fully understood but is thought to be related to its immunomodulatory effects. Since hair follicles are sensitive to changes in immune activity and inflammation, altering immune responses can temporarily disrupt hair growth. This is not the same as permanent hair loss or scarring alopecia; rather, it is a reversible condition where hair regrowth typically resumes once the body adapts or after discontinuation of the drug.
Patients experiencing hair thinning on Tecfidera should not stop or change their medication dose without consulting their neurologist. Hair thinning alone is usually not a reason to discontinue treatment, especially since Tecfidera plays a crucial role in managing MS symptoms and progression. Doctors may offer supportive advice or treatments to help manage hair health during this period.
Other factors can also contribute to hair thinning in people with MS, including the disease itself, stress, nutritional deficiencies, or other medications. Therefore, it can sometimes be challenging to attribute hair thinning solely to Tecfidera without considering these additional influences.
In summary, while Tecfidera can cause hair thinning as a side effect, it is typically mild, temporary, and reversible. Patients should monitor their symptoms and discuss any concerns with their healthcare provider to ensure the best balance between managing MS and maintaining quality of life.
