How Blood Thinners May Influence Alzheimer’s Progression
Blood thinners, commonly prescribed to prevent strokes and heart attacks, may have an unexpected influence on Alzheimer’s disease progression. Recent research has shed light on the potential benefits and risks of these medications for older adults, particularly those at risk for or already experiencing cognitive decline.
A study published in February 2025 found that stopping anticoagulant medications in older patients with atrial fibrillation significantly increased their risk of stroke and death[2][5]. The research, conducted by the University of Bath, revealed that the risks of stroke and death were three times higher during periods when patients were not receiving anticoagulation therapy. This suggests that the benefits of blood thinners often outweigh the potential risks, even in older adults who may be more prone to falls and bleeding.
Interestingly, the use of statins, another class of medications commonly prescribed to lower cholesterol, has been associated with higher cortical thickness in early cognitive decline[1]. This finding implies that statins may have neuroprotective effects, potentially slowing down neurodegenerative changes in the brain. The study, published in early 2025, observed increased cortical thickness in multiple brain regions across healthy controls, individuals with mild cognitive impairment, and those with Alzheimer’s disease who were taking statins.
While these findings are promising, it’s important to note that the relationship between blood thinners and Alzheimer’s progression is complex. Some antiamyloid medications used to treat Alzheimer’s disease may interact with blood thinners, potentially increasing the risk of side effects[4][7]. For instance, the use of anticoagulants or antiplatelet therapy in conjunction with newer Alzheimer’s treatments like donanemab (Kisunla) requires careful consideration due to the potential risk of amyloid-related imaging abnormalities (ARIA).
The impact of blood thinners on brain health extends beyond just Alzheimer’s disease. Research has shown that direct oral anticoagulants may reduce the risk of dementia in Asian patients with atrial fibrillation compared to traditional blood thinners[10]. This suggests that the choice of blood thinner could have implications for long-term cognitive health.
It’s worth noting that the side effects of blood thinners tend to diminish over time[8]. Common side effects include nosebleeds and blood in the urine, but these often become less severe as the body adjusts to the medication. This is encouraging news for patients who require long-term anticoagulation therapy.
For those concerned about brain health and cognitive function, lifestyle factors remain crucial. Exercise, proper nutrition, and mental challenges can all contribute to maintaining and even enhancing brain performance[3]. Dr. Tommy Wood, a leading neuroscientist, emphasizes the importance of cognitive stimulation and addressing nutrient deficiencies for optimal brain health.
In conclusion, while blood thinners play a vital role in preventing strokes and other cardiovascular events, their impact on Alzheimer’s progression is still being unraveled. The decision to use these medications should be made on an individual basis, weighing the potential benefits against the risks. As research continues to evolve, it’s clear that a holistic approach to brain health, combining appropriate medical interventions with lifestyle modifications, offers the best chance of maintaining cognitive function as we age.
