Does Intermittent Fasting Reduce Alzheimer’s Risk?

Intermittent fasting has been gaining attention for its potential benefits on health, including its impact on Alzheimer’s disease. Recent studies suggest that this eating pattern might help reduce the risk or slow the progression of Alzheimer’s by addressing one of its key symptoms: disrupted circadian rhythms.

Alzheimer’s disease affects millions of people worldwide, causing memory loss and cognitive decline. One common issue faced by those with Alzheimer’s is the disruption of their internal body clock, which can lead to sleep problems and worsened cognitive function at night. For a long time, these disruptions were seen as symptoms of the disease. However, new research indicates that they might actually contribute to the progression of Alzheimer’s.

A study from the University of California San Diego School of Medicine explored the effects of time-restricted feeding, a form of intermittent fasting, on mice with Alzheimer’s-like conditions. The mice were allowed to eat only within a six-hour window each day, which translates to about 14 hours of fasting for humans. The results were promising: these mice showed improved memory, reduced nighttime hyperactivity, and consistent sleep patterns compared to those with unrestricted access to food.

Moreover, the study found molecular improvements in the mice on the time-restricted feeding schedule. There was a reduction in the accumulation of amyloid proteins in the brain, which is a hallmark of Alzheimer’s disease. This suggests that intermittent fasting could potentially modify the course of Alzheimer’s by stabilizing disrupted circadian rhythms.

While these findings are promising, it’s important to note that they are based on animal studies. Researchers are now looking forward to conducting human clinical trials to confirm these results. If successful, this approach could offer a simple lifestyle change that improves the lives of people with Alzheimer’s and their caregivers.

In addition to intermittent fasting, other lifestyle interventions such as a nutrient-dense diet, regular exercise, and maintaining good cardiovascular health are also being explored for their potential to reduce Alzheimer’s risk. For instance, following the American Heart Association’s Life’s Simple 7 guidelines for cardiovascular health has been linked to lower biomarkers for neurodegenerative diseases.

Overall, while intermittent fasting shows promise, it’s crucial to consult with healthcare professionals before making significant changes to your diet or lifestyle.