Can diet and nutrition affect non-Hodgkin’s lymphoma outcomes?

Diet and nutrition can significantly influence the outcomes of non-Hodgkin’s lymphoma (NHL) by supporting the immune system, managing treatment side effects, and potentially improving overall survival and quality of life. While diet alone cannot cure NHL, proper nutritional strategies can enhance the body’s ability to cope with cancer and its treatments, reduce complications, and promote recovery.

Non-Hodgkin’s lymphoma is a type of blood cancer affecting the lymphatic system, which plays a crucial role in immune function. Because cancer and its treatments such as chemotherapy and radiation can weaken the immune system and cause side effects like fatigue, nausea, and loss of appetite, maintaining good nutrition becomes essential. A well-balanced diet rich in nutrients helps repair tissues, maintain muscle mass, and support immune defenses, all of which are critical during and after treatment.

Key dietary principles for those with NHL include:

– **Eating frequent small meals**: Consuming 5-6 small meals or “mini” meals every few hours can help maintain energy levels and manage appetite changes caused by treatment.

– **Prioritizing protein intake**: Protein is vital for repairing cells and tissues damaged by cancer and treatment. Sources include lean meats, poultry, fish, eggs, dairy, legumes, nuts, and seeds. For those with mouth sores or difficulty chewing, softer protein options like nut butters or smoothies can be helpful.

– **Including whole grains**: Whole grains such as oatmeal, brown rice, whole wheat bread, and whole grain pasta provide carbohydrates for energy and fiber to support digestive health.

– **Eating a variety of fruits and vegetables daily**: Fruits and vegetables are rich in antioxidants, vitamins, and minerals that help fight oxidative stress and inflammation. Cruciferous vegetables like broccoli, cabbage, cauliflower, kale, and Brussels sprouts are especially beneficial due to compounds like sulforaphane, which may protect healthy cells and support immune function.

– **Choosing healthy fats**: Healthy fats from sources like olive oil, avocados, nuts, seeds, and fatty fish support brain health and reduce inflammation. Fried and greasy foods should be avoided.

– **Limiting added sugars and processed foods**: Foods high in added sugars and heavily processed items can promote inflammation and provide little nutritional benefit, potentially undermining immune health.

– **Staying well-hydrated**: Adequate fluid intake is crucial, especially since treatments can cause dehydration through side effects like vomiting or diarrhea. Drinking water, broths, and electrolyte-rich fluids helps maintain hydration and supports overall bodily functions.

– **Practicing food safety**: Because cancer treatments can weaken the immune system, it is important to avoid foodborne infections by thoroughly washing fruits and vegetables, cooking foods to proper temperatures, and handling food hygienically.

Nutritional support can also help manage specific treatment-related side effects:

– **Nausea and vomiting**: Eating bland, easy-to-digest foods in small amounts can reduce discomfort.

– **Mouth sores**: Soft, moist foods and avoiding spicy or acidic items can ease pain.

– **Fatigue**: Balanced meals with adequate protein and carbohydrates provide sustained energy.

– **Loss of appetite**: Nutrient-dense snacks and small frequent meals can help maintain calorie intake.

Personalized nutrition plans developed with the guidance of dietitians or nutritionists specializing in cancer care can tailor dietary recommendations to individual needs, treatment protocols, and side effects. This holistic approach ensures that patients receive optimal nutritional support to enhance treatment tolerance, improve immune function, and potentially reduce the risk of cancer recurrence.

In addition to supporting treatment, certain foods contain bioactive compounds that may have cancer-fighting properties. For example, antioxidants found in berries, leafy greens, and nuts help neutralize harmful free radicals. Anti-inflammatory compounds in turmeric and omega-3 fatty acids in fish can modulate immune responses and inflammation, which are important in cancer progression.

While diet cannot replace medical treatment for NHL, it plays a complementary role i