Can Blood Pressure Medications Reduce Alzheimer’s Risk
Recent research suggests that blood pressure medications may help reduce the risk of Alzheimer’s disease. A study published in February 2025 found that people taking antihypertensive medications (AHMs) had lower levels of beta-amyloid in their brains compared to those not taking these drugs[1].
Beta-amyloid is a protein that builds up in the brains of Alzheimer’s patients, forming plaques that are thought to contribute to the disease. The study looked at over 400 older adults with hypertension, some of whom were taking blood pressure medications and some who were not. Those taking AHMs showed significantly less beta-amyloid accumulation in their brains.
Interestingly, a specific class of blood pressure drugs called renin-angiotensin system inhibitors (RASi) seemed to have the strongest effect in reducing beta-amyloid[1]. This suggests that certain types of blood pressure medications may be more beneficial than others when it comes to Alzheimer’s risk.
The link between blood pressure and brain health is not new. High blood pressure in midlife has long been associated with an increased risk of cognitive decline and dementia later in life[3]. What’s exciting about this new research is that it provides evidence for how blood pressure medications might directly impact the biological processes involved in Alzheimer’s disease.
However, it’s important to note that while these findings are promising, they don’t prove that blood pressure medications prevent Alzheimer’s. The study shows an association, but more research is needed to understand the exact relationship and mechanisms involved.
Other studies have also found mixed results when looking at blood pressure medications and dementia risk[5]. Some medications seem to lower risk, while others might increase it. This highlights the complexity of the relationship between cardiovascular health and brain health.
Despite the uncertainties, this research underscores the importance of managing blood pressure for overall health, including brain health. High blood pressure can damage blood vessels throughout the body, including in the brain, which may contribute to cognitive problems over time.
For those concerned about their brain health, working with a doctor to keep blood pressure under control is a good strategy. This might involve lifestyle changes like exercise and a healthy diet, as well as medication if necessary. While we can’t say for certain that blood pressure medications will prevent Alzheimer’s, maintaining healthy blood pressure is beneficial for many aspects of health.
As research continues, we may gain a clearer understanding of how specific blood pressure medications affect brain health and Alzheimer’s risk. For now, the best approach is to focus on overall cardiovascular health as part of a strategy to keep your brain healthy as you age.
