Benadryl PM contains diphenhydramine, an antihistamine with strong anticholinergic properties, commonly used as a sleep aid and allergy medication. For Alzheimer’s patients, the safety of Benadryl PM is a significant concern because anticholinergic drugs like diphenhydramine can worsen cognitive function and potentially accelerate dementia progression.
Diphenhydramine works by blocking acetylcholine, a neurotransmitter essential for memory and learning. Alzheimer’s disease already involves a deficit in acetylcholine, so further blocking this neurotransmitter can exacerbate symptoms such as confusion, memory loss, and cognitive decline. Research published in reputable journals such as JAMA Neurology and JAMA Internal Medicine has shown that the use of anticholinergic medications is associated with increased brain atrophy, clinical decline, and a higher risk of developing dementia over time[2].
Specifically, the 2016 JAMA Neurology study concluded that anticholinergic medication use correlates with brain atrophy and dysfunction, suggesting that older adults should avoid these drugs if alternatives exist[2]. Similarly, a 2015 JAMA Internal Medicine article found that higher cumulative use of anticholinergic drugs increases dementia risk, emphasizing the importance of minimizing their use in older populations[2].
For Alzheimer’s patients, who already have compromised cognitive function, taking Benadryl PM can lead to increased confusion, sedation, and worsening memory problems. The sedative effects of diphenhydramine can also increase the risk of falls, respiratory issues, and pneumonia, which are particularly dangerous in elderly patients with dementia[1].
Moreover, combining Benadryl PM with other medications common in older adults can increase risks. For example, mixing diphenhydramine with other antihistamines or central nervous system depressants like alcohol can cause severe drowsiness, dizziness, and confusion[3]. This polypharmacy risk is especially relevant for Alzheimer’s patients who often take multiple medications.
Medical experts generally advise against the use of diphenhydramine-containing products for sleep in older adults, especially those with dementia or Alzheimer’s disease. Instead, non-pharmacological approaches to managing sleep disturbances are preferred, such as improving sleep hygiene, establishing regular sleep routines, and addressing underlying medical conditions that disrupt sleep[5].
If medication is necessary, doctors may consider alternatives with fewer anticholinergic effects or prescribe medications specifically approved for sleep disorders in older adults, but these come with their own risks and must be carefully managed[5].
In summary, Benadryl PM is not considered safe for Alzheimer’s patients due to its anticholinergic effects, which can worsen cognitive decline and increase the risk of adverse events. Safer alternatives and non-drug strategies should be prioritized, and any medication use should be closely supervised by healthcare professionals knowledgeable about dementia care[1][2][5].
Sources:
[1] Neural Effects – What Can Make Dementia Worse?
[2] Peoples Pharmacy – Sleeping Pills for Seniors: A Scary Solution for Insomnia
[3] BuzzRx – Medications That Should Never Be Combined with Benadryl
[5] SingleCare – Is it safe to take OTC sleep aids every night?
