Lisinopril is a medication commonly used to treat high blood pressure, also known as hypertension. It belongs to a class of drugs called ACE inhibitors, which work by relaxing blood vessels so the heart does not have to pump as hard. Many people with Alzheimer’s disease also have high blood pressure, so it is important to know if lisinopril is safe for them.
## What Is Alzheimer’s Disease?
Alzheimer’s disease is a brain disorder that slowly destroys memory and thinking skills. Over time, it can make it hard for a person to carry out even simple tasks. The exact cause is not fully understood, but it involves changes in the brain, including the buildup of certain proteins called amyloid plaques and tau tangles[1]. There is no cure, but treatments can help manage symptoms.
## High Blood Pressure and Alzheimer’s Disease
High blood pressure is common in older adults, including those with Alzheimer’s disease. Research shows that controlling blood pressure may help reduce the risk of cognitive decline and dementia, including Alzheimer’s disease[2]. This means that treating high blood pressure could be especially important for people with Alzheimer’s.
## Is Lisinopril Safe for People with Alzheimer’s Disease?
There is no direct evidence from large clinical trials specifically studying lisinopril in people with Alzheimer’s disease. However, lisinopril is widely used in older adults, including those with memory problems, and is generally considered safe when prescribed by a doctor. It is important to note that lisinopril is usually better tolerated than some other blood pressure medications, such as nifedipine, with fewer side effects reported[4].
## Possible Side Effects
Like all medications, lisinopril can cause side effects. Common ones include dizziness, cough, headache, and tiredness. More serious side effects, such as kidney problems or very low blood pressure, are rare but can happen, especially in older adults or those with other health problems. People with Alzheimer’s disease may have trouble communicating if they feel unwell, so caregivers should watch for any changes in behavior or health.
## Medication Adherence in Alzheimer’s Disease
Taking medications as prescribed is important for managing high blood pressure and other conditions. However, people with Alzheimer’s disease may forget to take their medicines or take them incorrectly. Poor adherence to medications can lead to worse health outcomes, including higher risk of hospitalization and death[3]. Caregivers and family members can help by setting up reminders, using pill organizers, or working with healthcare providers to simplify medication routines.
## Other Treatments for Alzheimer’s Disease
While lisinopril is used for high blood pressure, it is not a treatment for Alzheimer’s disease itself. The main medications for Alzheimer’s are drugs like donepezil, which help with memory and thinking symptoms[6]. Non-drug approaches, such as staying active, eating a healthy diet, and engaging in social activities, are also important parts of care.
## What Should You Do?
If you or a loved one has Alzheimer’s disease and high blood pressure, talk to your doctor about the best treatment plan. Your doctor will consider overall health, other medications, and any side effects when choosing a blood pressure medicine. Regular check-ups are important to make sure the treatment is working and to catch any problems early.
## Key Points to Remember
– Lisinopril is commonly used to treat high blood pressure and is generally safe for older adults, including those with Alzheimer’s disease[4].
– Controlling high blood pressure may help reduce the risk of further cognitive decline in people with Alzheimer’s disease[2].
– Side effects are possible but usually mild. Caregivers should watch for any changes in health or behavior.
– Taking medications as prescribed is crucial. People with Alzheimer’s may need help remembering to take their medicines[3].
– Lisinopril does not treat Alzheimer’s disease itself. Other medications and lifestyle changes are used for that purpose[6].
– Always consult a healthcare provider before starting or changing any medication.
## Sources
[1] Frontiers in Aging Neuroscience, 2025
[2] American Heart Association, 2025
[3] Open Heart, 2025
[4] DrOracle, 2025
[6] DrOracle, 2025
